CROCIN AS NEUROPROTECTIVE AGONIST IN OXIDATIVE DAMAGE AND COGNITIVE DYSFUNCTION INDUCED BY ALUMINIUM CHLORIDE AND COLCHICINE IN RODENTS

The main constituent of saffron, Crocus sativus L., is called Crocin (CR). Water-soluble carotenoids in CR possesses anti-inflammatory, analgesic, anti-edematous, as well anti-oxidant properties, to increase the number microtubules sheep brain and have neuroprotective effects. For example, Alzheimer's disease (AD), where harm hippocampal cortical neurons results memory cognitive impairment, amyotrophic lateral sclerosis (ALS), weakness muscle brought on by degeneration spinal, bulbar, motor neurons, are disorders which characterized progressive irreversible loss neurons. In current investigation, we evaluated CR's ability protect from oxidative that Colchicine (Col) Aluminum chloride (ALCL) induce. GSH level, SOD, besides catalase reduced Col model's Col-treated group but was practically returned normal received CR. When given instead Col, levels MDA, acetylcholine esterase, nitric oxide nearly levels. However, Morris water maze test, significantly reduces time it takes reach platform (escape latency time), indicating learning improvement. Corresponding this, passive avoidance transfer delay did not CR-treated group. Similar outcomes aluminium model were attained. Thus, present study comes conclusion can be utilized treat stress illnesses linked dysfunction, such AD Parkinson’s diseases shown against rodents resultantly. KEYWORDS: Crocin, Aluminium Chloride, Alzheimer’s disease, stress, Neurodegeneration